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. 2012 Jan 27;2(1):e54. doi: 10.1038/bcj.2011.52

Table 1. Classification of lead anti-Fli-1 compounds.

Drug classes Number of drugs Drug name Effective dose (μ) IC(50)a
Cardenolides 10 Peruvoside, digitoxin, dihydroouabain, quabain, strophanthidin, proscillaridin A, cymarin, convalatoxin, gitioxin, lanatoside C 0.165–0.33
Calcium ionophores 5 Calcimycin, alexidine dihydrochloride, gossypol-acetic acid complex, oligomycin A, thapsigargin 0.66–1.33
Topoisomerase I inhibitors 1 Camptothecin 0.33
Protein synthesis inhibitors 2 Emetine, anisomycin 0.165–0.66
Chemotherapeutic drugs 4 Etoposide, dactinomycin, cycloheximide, puromucine dihydrochloride, 0.66–2.66
Others 8 Cedrelone, 5-azacytidine, anthothecol, cephaline, dihydrochloride heptahydrate, helveticoside, deacetoxy-7-oxogedunin, pyrvinion pamoate, cantharidin acid 0.66–5.62

Compound library screening resulted in the identification of six drug classes with the indicated number in each class.

a

IC(50) was calculated as the lowest drug concentration resulting in a 50% reduction of EWS/Fli-1 luciferase activity. Column 3 displays one example of each inhibitor drug class. Column 4 displays the calculated range of effective dose response for each class.