Table 2. Clinical characteristics.

Characteristic	First data set (N1=121)			Second data set (N2=166)			Overall (N=287)
	Bone marrow uninvolved (N=69)	Bone marrow involved (N=52)	P-value	Bone marrow uninvolved (N=74)	Bone marrow involved (N=92)	P-value	P-value
Histological subtype—%			0.69			0.55	0.92
Grade 1	29	29		53	48
Grade 2	55	50		43	48
Grade 3A	16	21		4	4
Male sex—%	49	56	0.48	54	49	0.51	0.95
Age >60 years—%	52	37	0.087	35	29	0.43	0.046
LDH elevated—%	33	31	0.77	20	36	0.028	0.17
Hemoglobin <12 g/dl—%	3	8	0.23	14	24	0.091	0.016
>4 nodal areas involved—%	13	56	<0.0001	35	71	<0.0001	<0.0001
B symptoms—%	14	33	0.017	23	24	0.89	0.099

Abbreviation: LDH, lactate dehydrogenase.