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A proposed model of cooperation between H-Ras and galectin-1 for radioresistance. Galectin-1 enhances activation (GTP form) of H-Ras following irradiation. Galectin-1 potentiates downstream signals of H-Ras, such as Raf-1 and ERK, that may mediate DNA damage repair33 and radioresistance.31, 32 Galectin-1 may regulate p21 expression36 through Raf-1.34 Hence, Raf-1 may have a significant role in galectin-1-mediated radioresistance
