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ER stress specifically activates the NLRP3 inflammasome. (a–c) LPS-primed bone marrow-derived macrophages from Nlrp3+/+, Nlrp3−/−, Asc+/+, Asc−/−, Nlrc4+/+ and Nlrc4−/− mice, respectively, were stimulated with MSU, tunicamycin, thapsigargin or BFA as indicated for 6 h, and analyzed by western blot
