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Comparison of cell sensitivity with chemotherapeutic agents between UDG+/+ and UDG−/− cells. The cytotoxicity induced by different chemotherapeutic agents was analyzed by clonogenic formation assay in UDG-proficient or -deficient cells (a) pemetrexed treatment (0–400 nM); (b) 5-FU treatment (0–20 μM); (c) temozolomide treatment (0–1500 μM; P-value=0.687); and (d) cisplatin treatment (0–40 μM, P-value=0.753). Results are representative of three independent experiments
