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MX synergistically enhances antitumor effect of pemetrexed. Human nonsmall cell lung cancer xenografts were grown in athymic nude mice. When tumor volume of H460 (a) or A549 (b) reached 100 mm3, mice received the treatment with PBS (control), MX (4 mg/kg), pemetrexed (150 mg/kg), and pemetrexed plus MX, i.p injection/daily for 5 days. Tumor volume was measured and used to determine the therapeutic effect
