Table2. Clonal analysis results of multidrug-resistant HBV strain in sera samples.

Clone	Sample						Mutation
		L80V	L91I	R120K	H126R	S135Y	V173L	L180M	A181V	M204I	L231V	Y245H	H248N
1	Sera, 11th month in ADV therapy		CTT → ATT	AGG → AAG	CAC → CGC	TCC → TAC							CAT¦AAT
2		TTA → GTA	CTT → ATT							ATG¦ATT		TAC¦CAC
3		TTA → GTA									CTG¦GTG
4									GCT¦GTT
5		TTA → GTA	CTT → ATT							ATG¦ATT		TAC¦CAC
6			CTT → ATT	AGG¦AAG	CAC¦CGC	TCC¦TAC							CAT¦AAT
		L80V	L91I	R120K	H126R	S135Y	V173L	L180M	A181V	M204V	L231V	Y245H	H248N
1	Sera, 4th month in ETV+TDF therapy		CTT → ATT	AGG¦AAG	CAC → CGC	TCC → TAC	GTG → TTG	CTG → ATG		ATG → GTG			CAT → AAT
2			CTT → ATT	AGG → AAG	CAC → CGC	TCC → TAC	GTG → TTG	CTG → ATG		ATG → GTG			CAT → AAT
3			CTT → ATT	AGG → AAG	CAC → CGC	TCC → TAC	GTG → TTG	CTG → ATG		ATG → GTG			CAT → AAT
4			CTT → ATT	AGG → AAG	CAC → CGC	TCC → TAC	GTG → TTG	CTG → ATG		ATG → GTG			CAT → AAT
5			CTT → ATT	AGG → AAG	CAC → CGC	TCC → TAC	GTG → TTG	CTG → ATG		ATG → GTG			CAT → AAT