TABLE 1.

Angiogenesis Inhibitors Generated as Cleaved Fragments from Larger Precursors

Inhibitors	Larger precursors	References
Angiostatin (Kringle1–3, 4)	Plasminogen	(O’Reilly, 1997)
Antithrombin	AaAT	(O’Reilly et al., 1999)
Arresten	Type IV collagen (α1)	(Colorado et al., 2000)
Canstatin	Type IV collagen (α2)	(Kamphaus et al., 2000)
Endostatin	Type XVIII collagen	(O’Reilly et al., 1997)
Heparin-binding fragment	Fibronectin	(Homandberg et al., 1985)
Kringle 5	Plasminogen	(Cao et al., 1997)
Kringle 1–5	Plasminogen	(Cao et al., 1999)
PEX	MMP-2	(Brooks et al., 1998)
PF-4, truncated fragment	Platelet factor-4	(Maione et al., 1990)
Prolactin, 16-kDa fragment	Prolactin	(Clapp et al., 1993)
Restin	Type XV collagen	(Ramchandran et al., 1999)
TSP-1	Thrombospondin	(Good et al., 1990)
Tumstatin	Type IV collagen (α3)	(Maeshima et al., 2000)
Vasostatin	Calreticulin	(Pike et al., 1998)
Vastatin	Type VIII collagen	(Xu et al., 2001)