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. Author manuscript; available in PMC: 2013 Jan 27.
Published in final edited form as: Chem Biol. 2012 Jan 27;19(1):140–154. doi: 10.1016/j.chembiol.2011.11.010

Figure 5. Evaluation of the functional selectivity with mutagenesis.

Figure 5

Figure 5

Mutation of the conserved Cys116 to Ser increases the IC50 for inhibition of JNK2 by over 100-fold for JNK-IN-7 and JNK-IN-8 but only by approximately 10-fold for JNK-IN-11.