Table 2.
Site-specific head and neck cancer associated with tobacco, alcohol, and HPV E6/E7 status.1
| Cases | Controls | Oral Cavity versus controls | Oropharynx versus controls | ||
|---|---|---|---|---|---|
| Oral cavity (N = 170) | Oropharynx (N = 74) | (N = 428) | OR2 (95% CI) | OR2 (95% CI) | |
| Characteristic | N (%) | N (%) | N (%) | ||
| Tobacco | |||||
| Never | 57 (33.7) | 10 (13.7) | 160 (37.7) | 1.0 | 1.0 |
| ≤30 | 44 (26.0) | 25 (34.2) | 142 (33.4) | 0.9 (0.5–1.4) | 2.1 (0.9–5.2) |
| >30 | 68 (40.2) | 38 (52.1) | 123 (28.9) | 1.5 (0.9–2.4) | 5.6 (2.3–13.7) |
| Alcohol | |||||
| Never | 60 (35.5) | 8 (11.0) | 184 (43.2) | 1.0 | 1.0 |
| ≤21 | 59 (34.9) | 37 (50.7) | 181 (42.5) | 1.1 (0.7–1.8) | 4.3 (1.7–10.4) |
| >21 | 50 (29.6) | 28 (38.4) | 61 (14.3) | 3.6 (2.1–6.2) | 11.7 (4.2–32.7) |
| Tobacco/alcohol | |||||
| Never/never | 42 (25.0) | 3 (4.1) | 100 (23.6) | 1.0 | 1.0 |
| ≤30/≤21 | 23 (13.7) | 14 (19.2) | 72 (17.0) | 1.0 (0.5–1.8) | 5.2 (1.2–21.7) |
| ≤30/>21 | 10 (6.0) | 8 (11.0) | 26 (6.1) | 1.4 (0.6–3.5) | 15.9 (3.2–80.2) |
| >30/≤21 | 22 (13.1) | 17 (23.3) | 55 (13.0) | 1.3 (0.6–2.4) | 16.6 (3.9–71.4) |
| >30/>21 | 39 (23.2) | 19 (26.0) | 29 (6.9) | 5.2 (2.6–10.5) | 34.6 (7.5–158.8) |
| HPV E6/E7 status1 | |||||
| Positive | 16 (9.4) | 47 (63.5) | 31 (7.2) | 1.7 (0.9–3.3) | 24.3 (12.9–45.8) |
| Negative3 | 154 (90.6) | 27 (36.5) | 397 (92.8) | 1.0 | 1.0 |
1Percentages based on available data; 2odds ratio adjusted by age (continuous), gender, HPV status, tobacco, and alcohol; 3HPV E6/E7 negative status for all types, E6/E7 positive status for HPV-16, -18, and/or -33.