Table 4.
Tobacco and alcohol status in head and neck cancer cases by HPV E6/E7 1,2 and tumor HPV status1 (N = 204).
| Risk factor | E6/E7 positive | E6/E7 negative | OR (95% CI) | Tumor positive3 | Tumor negative3 | OR (95% CI) |
|---|---|---|---|---|---|---|
| N (%) | N (%) | N (%) | N (%) | |||
| Prevalence | 52 (25.5) | 152 (74.5) | 53 (26.0) | 151 (74.0) | ||
| Tumor site | ||||||
| Oral cavity | 14 (26.9) | 131 (86.2) | 1.0 | 19 (35.9) | 126 (83.4) | 1.0 |
| Oropharynx | 38 (73.1) | 21 (13.8) | 17.3 (7.4–40.5) | 34 (64.2) | 25 (16.6) | 8.8 (4.1–19.0) |
| Tobacco4 | ||||||
| Never | 8 (15.7) | 49 (32.5) | 1.0 | 9 (17.3) | 48 (32.0) | 1.0 |
| ≤30 | 20 (39.2) | 37 (24.5) | 2.1 (0.8–5.7) | 23 (44.2) | 34 (22.7) | 3.0 (1.2–7.5) |
| >30 | 23 (45.1) | 65 (43.0) | 1.1 (0.4–3.1) | 20 (38.5) | 68 (45.3) | 1.2 (0.5–3.4) |
| ≤30 versus >30 | 1.9 (0.8–4.2) | 2.3 (1.1–5.1) | ||||
| Alcohol5 | ||||||
| Never | 7 (13.7) | 51 (33.6) | 1.0 | 8 (15.4) | 50 (33.1) | 1.0 |
| ≤21 | 24 (47.1) | 56 (36.8) | 2.3 (0.8–6.2) | 27 (51.9) | 53 (35.1) | 3.0 (1.2–7.8) |
| >21 | 20 (39.2) | 45 (29.6) | 2.1 (0.7–6.4) | 17 (32.7) | 48 (31.8) | 2.2 (0.7–6.8) |
| ≤21 versus >21 | 1.1 (0.5–2.5) | 3 (5.8) | 10 (6.7) | 1.3 (0.6–3.0) | ||
| Tobacco/alcohol6 | ||||||
| Never//never | 4 (7.8) | 38 (25.2) | 1.0 | 1.0 | ||
| ≤30/≤21 | 13 (25.5) | 21 (13.9) | 3.2 (0.9–12.0) | 15 (28.9) | 19 (12.7) | 4.2 (1.2–14.0) |
| ≤30/>21 | 4 (7.8) | 10 (6.6) | 1.8 (0.3–9.3) | 5 (9.6) | 9 (6.0) | 2.6 (0.6–11.8) |
| >30/≤21 | 8 (15.7) | 24 (15.9) | 1.6 (0.4–6.7) | 9 (17.3) | 23 (15.3) | 1.9 (0.5–6.8) |
| >30/>21 | 15 (29.4) | 34 (22.5) | 1.6 (0.4–5.9) | 11 (21.2) | 38 (25.3) | 1.2 (0.3–4.2) |
1Percentages based on available data; 2HPV E6/E7 seronegative for HPV-16, and -33; HPV E6/E7 seropositive for HPV-16 and/or -33; 3DNA negative for all HPV DNA types; DNA positive for HPV-16 and/or -33; 4adjusted for age (continuous), gender, tumor site (oral cavity, oropharynx), and average drinks/week (continuous); 5adjusted for age (continuous), gender, tumor site (oral cavity, oropharynx), and tobacco pack-years (continuous); 6adjusted for age (continuous) and gender.