Table 1.

Injection site microscopic findings in rabbits (combined sexes).

Day 3	Observations	Severity grade	Saline	EXP 9 mg/kg	EXP 18 mg/kg	EXP 30 mg/kg	Bsol 9 mg/kg
Brachial plexus, distal	Hemorrhage	minimal	0	0	1	0	1
		moderate	0	1	1	0	0
	Inflammation, granulomatous	minimal	0	3	1	1	0
	Inflammation, subacute	minimal	0	0	0	0	1
Brachial plexus, middle	Hemorrhage	minimal	0	2	0	1	0
		moderate	0	1	0	0	0
	Inflammation, granulomatous	minimal	0	1	1	3	0
	Inflammation, subacute	minimal	0	0	1	0	0
Brachial plexus, proximal	Hemorrhage	minimal	0	0	1	1	0
		mild	0	1	0	0	0
		moderate	0	1	0	0	0
	Inflammation, granulomatous	minimal	0	0	1	1	0
	Inflammation, subacute	minimal	0	1	1	0	0
Day 15
Brachial plexus, distal	Hemorrhage	minimal	0	1	1	0	0
		mild	0	0	1	1	0
		moderate	0	0	0	1	0
	Inflammation, subacute	minimal	0	1	0	0	0
Brachial plexus, middle	Fibrosis	minimal	0	0	0	0	1
	Hemorrhage	minimal	0	1	1	0	2
		mild	0	0	0	0	1
	Inflammation, granulomatous	mild	0	0	1	0	0
	Inflammation subacute	minimal	0	1	0	0	0
	Mineralization	minimal	0	0	1	0	0
Brachial plexus, proximal	Hemorrhage	minimal	0	2	0	0	0
		mild	0	1	1	1	0
		moderate	0	0	0	0	1

EXP, EXPAREL (bupivacaine liposome injectable suspension); Bsol, bupivacaine solution.

Note: number of animals examined was 4/group on Day 3 or Day 15.