Table 1.
List of miRNAs that are reported or have high probability to inhibit the expression of genes linked to neurodegenerative disease development.
| Disease | Risk gene | miRNA | References |
|---|---|---|---|
| Alzheimer's disease | A-beta | miR-101 | [10] |
| Parkinson's disease | α-synuclein | miR-7, miR-153 | [11] |
| Spinocerebellar ataxia type 1 (SCA1) | Ataxin 1 | miR-144, miR-107, miR-130, miR-19 | [12, 13] |
| Amyotrophic lateral sclerosis (ALS) | SOD1 | miR-206 | [14] |
|
| |||
| Spinocerebellar ataxia type 7 (SCA7) | Ataxin 7 | miR-199*, miR-141*, miR-200a* | [15, 16] |
| Huntington's disease | Huntingtin | miR-216*, miR-107*, miR-27ab*, miR-128* | [15, 16] |
*miRNAs that have high potential to inhibit ataxin 7 and Huntingtin gene expression as predicted by Target Scan (release 5.2).