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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Behav Brain Res. 2011 Sep 17;226(1):224–234. doi: 10.1016/j.bbr.2011.09.022

Fig. 4.

Fig. 4

Effect of bilateral OXO microinjections into the PPT on ACh levels in the VTA. Data are expressed as a percent of baseline (represented by the dotted line). (A) The time course of ACh in response to intra-PPT OXO (10 nM; solid triangles) or aCSF (open circles) microinjection and IP injection of saline (Sal; broken arrow) or MA (3.5 mg/kg; solid arrow) is shown in 20-min bins. (B) ACh samples were collapsed for each mouse after saline injection (Saline) and in the first 80 min after MA injection (3.5 mg/kg; MA) in each OXO treatment group for analysis. There was a significant increase in ACh levels following IP MA in both 10 nM OXO- (solid bar) and aCSF-pretreated (open bar) mice. Treatment group sample sizes are shown on their respective bar. **p = 0.001 vs. IP saline.