FIG. 3.

Schematic of GNB1L and corresponding protein and transmission of GNB1L variants in families with autism. A: The chromosome 22 translocation breakpoint lies in intron 7. The locations of the three unique variants found in ASD in the WD40 motifs are indicated. B: Affected individuals in all families have a diagnosis of autism or ASD, indicated by black fill. Up-arrow indicates an elevated BPASS social motivation and range of interest/flexibility scores; scores have a direct correlation with symptoms of ASD such that high scores are abnormal.