Figure 1.

Modeled cortisol response to CRH infusion by gender across pubertal stage based on a nonlinear mixed model with mean cortisol response given by:μ=θ₀ +θ₁ * (Time+Start) + θ₂ * T*exp(− θ₃ *T). CRH infusion occurs at Time=0; ensuring that nonlinear departure from baseline operates only in the post-infusion phase, T =max (0, Time). θ₀ (Baseline Cortisol) represents baseline cortisol at Time=0; θ₁ (Baseline Slope) is the slope of the underlying diurnal rhythm; θ₂ (Modulating Constant) is a constant that modulates magnitude of the peak change from baseline; and θ₃ (Reactivity/Recovery Rate) is the rate of reactivity and recovery from CRH challenge.