Table 5.
Head Injury × Rep1 Interaction. Genotype-Specific Risk Associated with a Head Injury, Relative to No Head Injury (Odds Ratio (95% CI))a
| Genotype | FAME | SEARCH | Pooledd | |||
|---|---|---|---|---|---|---|
| All subjects (n = 418) |
Non- Hispanic Whites (n = 408) |
All subjects (n = 546) |
Non- Hispanic Whites (n = 479) |
All subjects (n = 964) |
Non- Hispanic Whites (n = 887) |
|
|
Dominant
modelb |
||||||
| S* | 0.5 (0.1-1.5) | 0.5 (0.1-1.5) | 0.9 (0.5-1.7) | 0.7 (0.4-1.2) | 0.8 (0.4-1.3) | 0.7 (0.4-1.2) |
| M_M | 1.8 (0.8-4.3) | 1.8 (0.7-4.2) | 1.3 (0.7-2.5) | 1.1 (0.6-2.3) | 1.5 (0.9-2.6) | 1.3 (0.8-2.3) |
| L* | 5.4 (1.5-19) | 5.8 (1.6-21) | 2.3 (0.6-9.2) | 3.1 (0.6-15) | 3.5 (1.4-9.2) | 4.1 (1.5-11) |
| p-interaction | 0.022 | 0.021 | 0.45 | 0.25 | 0.022 | 0.008 |
|
| ||||||
|
Alternative
modelfc |
||||||
| 259* | 0.7 (0.2-2.1) | 0.6 (0.2-2.0) | 1.0 (0.5-1.9) | 0.8 (0.4-1.5) | 0.9 (0.5-1.5) | 0.7 (0.4-1.3) |
| 261_261 | 1.5 (0.6-3.8) | 1.6 (0.6-3.9) | 1.2 (0.6-2.4) | 1.1 (0.6-2.3) | 1.3 (0.7-2.3) | 1.3 (0.8-2.3) |
| 263* | 8.4 (2.0-36) | 8.2 (1.9-35) | 3.5 (0.7-18) | 3.3 (0.6-17) | 6.3 (2.0-20) | 5.9 (1.9-19) |
| p-interaction | 0.018 | 0.018 | 0.30 | 0.21 | 0.006 | 0.006 |
a
Adjusted for age, gender, race, and smoking
b
S* = short/short or short/medium; M_M = medium/medium; L* = medium/long or long/long;
c
Excludes offsetting short and long allele combinations and rare alleles (257 and 265); 259* = 259_259 or 259_261; 263* = 261_263 or 263_263
d
Additionally adjusted for study and smoking*study