Figure 6. Correlation between serum estradiol concentration and ventilatory responses to hypoxia and hypercapnia.
A. Correlation between serum estradiol levels and change (Δ) in ventilation in hypoxia in P10-11, P12-13, and P14-15 male and female rats. There is a strong negative correlation in male rats (R2 = 0.999) whereas in female rats there is no correlation (R2 = 0.098). B. Correlation between serum estradiol levels and change (Δ) in ventilation in hypercapnia in P10-11, P12-13, and P14-15 male and female rats. There is a strong negative correlation in male rats (R2 = 0.908) whereas in female rats there is a less robust correlation (R2 = 0.613).