Table 1. Body Weight, Temperature and Ventilation in Room Air (RA), Hypoxia (Hx) and Hypercapnia (CO2) in neonatal, prepubertal and young adult male and female rats.
Shown are the number of animal in each group (n), body temperature (Tb) before and after study, plethysmograph temperature, ventilation, tidal volume, and breathing frequency, in male and female rats at P10-11, P12-13, P14-15, P30 and P90. Values are means ± SEM.
| Male | Female | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Age | P10-11 | P12-13 | P14-15 | P30 | P90 | P10-11 | P12-13 | P14-15 | P30 | P90 | |
| n | 14 | 16 | 14 | 6 | 7 | 14 | 19 | 15 | 11 | 7 | |
| Initial Tb °C | 34.8±0.3 | 36.0±0.1 | 36.4±0.2 | 37.8±0.2 | 37.0±0.3 | 34.9±0.3 | 35.9±0.1 | 36.6±0.2 | 37.7±0.1 | 37.8±0.3 | |
| box temp °C | 26.1±0.1 | 25.5±0.1 | 25.5±0.3 | 23.6±0.2 | 23.0±0.2 | 25.9±0.1 | 26.4±0.5 | 25.8±0.3 | 23.5±0.2 | 22.4±0.2 | |
| weight (g) | 22.7±1.1 | 29.3±1.1 | 35.9±1.4 | 108.6±2.6*† | 387.2±0.0*† | 21.3±1.0 | 26.1±1.0 | 33.3±1.1 | 90.1±1.9* | 222.6±7.2* | |
| RA | Minute Ventilation (ml/min/100g) | 69.4±8.3 | 32.2±2.4*† | 66.9±5.1* | 55.5±4.4 | 35.5±7.1 | 72.5±5.7 | 57.9±5.2 | 59.9±4.7 | 53.4±3.3 | 33.7±7.6 |
| Tidal Volume (ml/br) | 0.47±0.06 | 0.23±0.02*† | 0.47±0.04* | 0.46±0.03 | 0.38±0.07 | 0.50±0.04 | 0.40±0.04 | 0.44±0.04 | 0.44±0.02 | 0.43±0.04 | |
| Breathing Frequency (br/min) | 150±3.8 | 141±3.4 | 146±4.3 | 121±4.3* | 86±6.3* | 147±5.7 | 150±5.2 | 143±6.8 | 120±3.3* | 79±4.7* | |
| Hx | Minute Ventilation (ml/min/100g) | 101.0±8.9 | 47.0±4.9*† | 109.5±11.6* | 64.7±6.6* | 48.4±9.8 | 94.3±5.9 | 78.1±7.5 | 96.2±5.0 | 60.8±3.2* | 43.4±3.0 |
| Tidal Volume (ml/br) | 0.56±0.06 | 0.27±0.03*† | 0.58±0.59* | 0.47±0.04 | 0.39±0.07 | 0.52±0.04 | 0.44±0.04 | 0.54±0.04 | 0.44±0.22 | 0.45±0.04 | |
| Breathing Frequency (br/min) | 185±7.6 | 178±3.8 | 190±6.7* | 136±7.3* | 120±7.1† | 186±8.2 | 180±6.3 | 185±7.4 | 138±7.1* | 98±4.9* | |
| CO2 | Minute Ventilation (ml/min/100g) | 160.6±20.6 | 70.7±5.1* | 249.4±41.2*† | 145.9±14.7* | 95.9±22.7 | 111.2±21.5 | 85.4±10.2 | 120.1±6.1 | 143.9±6.8 | 80.6±12.9 |
| Tidal Volume (ml/br) | 1.03±0.11† | 0.41±0.03* | 1.06±0.14*† | 0.76±0.08 | 0.60±0.12 | 0.69±0.17 | 0.53±0.04 | 0.64±0.04 | 0.73±0.04 | 0.59±0.05 | |
| Breathing Frequency (br/min) | 155±7.8 | 173±7.6* | 226±8.1† | 193±3.3 | 147±0.1* | 171±13.3 | 166±16.3 | 193±12.1 | 198±3.9 | 133±15.5* | |
| Final Tb °C | 34.7±0.4 | 36.1±0.2 | 36.6±0.3 | 37.5±0.1 | 37.4±0.2 | 34.8±0.3 | 36.0±0.1 | 36.5±0.2 | 37.4±0.1 | 37.5±0.2 | |
*
P<0.05 vs. previous age group of the same sex
†
P<0.05 vs. age-matched female