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. 2009 Dec 28;10(1):97–111. doi: 10.3390/s100100097

Figure 2.

Figure 2.

Mechanisms of inflammasome activation. Three different NLRs regulate the inflammasome. The NLRC4 inflammasome is triggered by microbial components secreted by bacterial secretion systems. The NLRP1/NALP1 inflammasome is associated with susceptibility to the Bacillus anthracis lethal toxin. Microbial toxins and danger signals trigger the NLRP3/NALP3 inflammasome. Crystals cause lysosome damage and protein leakage to the cytosol. Response to the NLRP3/NALP3 inflammasome triggers reactive oxygen species and potassium efflux although it is not clear how the signaling cascade operates.