Skip to main content
. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Ann Neurol. 2012 Jan;71(1):93–109. doi: 10.1002/ana.22627

Figure 2.

Figure 2

Diffuse astroglial reaction in chronic WMI defined by astrocyte quantification. (A, B) Typical morphology of GFAP-labeled astrocytes in white matter from control (A) and WMI (B) cases at 29 weeks PCA selected from the retrospective cohort (Table 1). (C) Schematic representation of the regions of interest (ROIs) selected for astrocyte quantification. The ROIs for control cases (control/peri-control; left) were age- and region-matched to corresponding ROIs for WMI cases (lesion/peri-lesion; right). (D) Astroglial quantification identified significant graded astroglial reaction in lesion and peri-lesion ROIs that was also significantly elevated relative to control and peri-control ROIs, respectively (*p<0·0001). Scale bars: 25 µm.