Table 1.
Summary of Clinical and Neuropathological Data for 24 Cases Studied from Paraffin-Embedded Archival Tissue
| Case | Primary Diagnosis |
PCA | ST | PMI | Sex | Clinical Diagnosis, Cause of Death | Other Neuropathological Diagnosis |
|---|---|---|---|---|---|---|---|
| 1 | WMI | 32 | <1 | 24 | M | HF-NI of uncertain etiology, pulmonary hypoplasia | None |
| 2 | WMI | 32 | 1 | 24 | F | Meningitis and ventriculitis (E. coli), DIC | Meningitis and ventriculitis, germinal matrix hemorrhage, cerebellar hemorrhage |
| 3 | WMI | 32 | 3 | 24 | F | IUGR, neonatal adenovirus infection with necrotizing bronchitis | PV infarcts, hippocampal and subicular necrosis |
| 4 | WMI | 32 | 6 | 48 | M | BPD, sepsis, renal failure | None |
| 5 | WMI | 34 | <1 | 72 | M | VATER complex, hypoventilation secondary to airway obstruction | Cerebellar heterotopia |
| 6 | WMI | 34 | 2 | 72 | M | Acute severe chorioamnionitis and funisitis, RDS, pneumonia | Neuronal loss in thalamus, brainstem, and hippocampus |
| 7 | WMI | 34 | 2 | 24 | M | HMD/RDS, sepsis, recurrent cardiac decompensation | Neuronal loss and gliosis in thalamus, kernicterus in subthalamic body, floor of 4th ventricle, and pontomedullary junction, hemorrhage of choroid plexus, necrosis of anterior horn of spinal cord |
| 8 | WMI | 37 | 1 | 72 | F | HMD/RDS, pneumonia, | None |
| 9 | WMI | 37 | 2 | 48 | M | HMD/RDS, unilateral left lung agenesis, necrotizing tracheobronchitis | Ventricular enlargement, resorbing germinal matrix hemorrhage, choroids plexus hemorrhage |
| 10 | WMI | 38 | <1 | 24 | M | Meconial aspiration, gastroschisis | Neuronal loss in basis pontis |
| 11 | WMI | 38 | 1 | 48 | M | Transposition of great arteries, perioperative complications | None |
| 12 | WMI | 38 | 9 | 24 | M | Beckwith-Weideman syndrome, BPD, pneumonia | Subcortical heterotopias, hydromyelia in spinal cord |
| 13 | WMI | 38 | 13 | 24 | F | HMD/RDS, BPD, NEC with candida peritonitis | Partial agenesis of CC, old IVH |
| 14 | WMI | 40 | <1 | 24 | M | Hypoplastic left heart syndrome with severe aortic valve stenosis, hypoplasia of left ventricle and atrium, congestive heart failure | None |
| 15 | WMI | 41 | 2 | 24 | M | Pulmonary valve atresia with tricuspid incompetence, PDA, congestive heart failure | Cortical gliosis and neuronal loss |
| 16 | WMI | 43 | 18 | 24 | M | BPD, recurrent NEC, sepsis (Enterobacter), myocardial ischemia, renal failure | Neuronal injury and neuro-axonal swelling in pons, lateral geniculate body, hippocampus, cerebral cortex with dilated ventricles |
| 17 | WMI | 48 | 22 | 48 | F | HF-NI secondary to in utero WPW and heart failure, maternal mirror syndrome | None |
| 18 | Control | 31 | <1 | 72 | M | Bladder outlet obstruction, imperforate anus, diaphragmatic hernia | None |
| 19 | Control | 33 | 15/7 | 20 | F | Monozygotic twin, IUGR, renal hypoplasia | Mild hippocampal neuronal injury |
| 20 | Control | 332/7 | <1 | 20 | M | Tracheal agenesis, esophageal stenosis, interrupted aorta | Mild subarachnoid hemorrhage |
| 21 | Control | 35 | <1 | 36 | M | HF-NI | None |
| 22 | Control | 363/7 | <1 | 21 | M | Bladder outlet obstruction, pulmonary hypoplasia | Mild WM gliosis, cerebellar heterotopias |
| 23 | Control | 38 | <1 | 12 | M | HMD/RDS | Mild hippocampal neuronal injury |
| 24 | Control | 49 | 152/7 | 36 | F | Tetralogy of Fallot, IUGR | Early cerebral edema |
Data includes postconceptional age (PCA) in weeks at time of death (derived from gestational age at birth and survival time (ST) in weeks after birth), estimated post-mortem interval (PMI) in hours before tissue collection at autopsy and clinical data pertinent to the primary diagnosis.
BPD = bronchopulmonary dysplasia; CC = corpus callosum; DIC = disseminated intravascular coagulation; GMH = germinal matrix hemorrhage; HF-NI = hydropsfetalis, nonimmune; HMD/RDS = hyaline membrane disease/respiratory distress syndrome; IUGR = intrauterine growth retardation; IVH = intraventricularhemorrhage; NEC = necrotizing enterocolitis; PDA = patent ductusarteriosius; PV = periventricular; RDS = respiratory distress syndrome; VATER complex = Vertebral anomalies, anal atresia, tracheo-esophageal fistula, radial dysplasia, and cardiac anomalies; VSD = ventricular septal defect; WM = white matter; WMI = white matter injury; WPW = Wolf-Parkinson-White.