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. 2011 Dec 14;287(5):2943–2947. doi: 10.1074/jbc.C111.327627

FIGURE 2.

FIGURE 2.

CD8+ T cells are the predominant source of IL-17 that induces intestinal inflammation in TGF-βRIIDN mice, and unlike Th17 cells, in vivo differentiation of Tc17 cells requires neither TGF-β nor IL-4 or IFN-γ. A, cytokines produced by CD8+ T cells derived from wild type and TGF-βRIIDN mice. B, FACS analysis to show IL-17 production by CD8+ T cells from TGF-βRIIDN mice. C, histological sections to show that anti-CD8 antibodies profoundly reduced clinical scores of intestinal inflammation in TGF-βRIIDN mice. The experiment shown is representative of three independent experiments (four mice in each group). D, serum cytokines in C57BL/6 and Stat6−/−T-bet−/−TGF-βRIIDN mice at the indicated ages. E, cytokines from differentiated CD4+ T cells from C57BL/6, TGF-βRIIDN, and Stat6−/−T-bet−/−TGF-βRIIDN mice. F, IL-17 production by CD8+ T cells from TGF-βRIIDN and Stat6−/−T-bet−/−TGF-βRIIDN mice. The experiment shown is representative of three independent experiments (six mice in each group).