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Effects of BCTC on single-channel WT TRPM8 currents. A, representative traces of single-channel activity in 0 (control), 1, and 10 μm BCTC as indicated recorded from the same patch at room temperature. B, open and closed one-dimensional dwell-time histograms for the same conditions. The histograms have been fitted (continuous lines) by the sum of two open and five closed exponential components (dashed lines). sq., square. C, representative two-dimensional dwell-time distributions.
