Table 2.
C. Elegans Genes with Potential Roles in Dauer Having S. Stercoralis Homologs
| S. stercoralis homologs | C. elegans gene | Description | E-value | Possible ortholog? | Other homologsa gene | Description | E-value | S. stercoralis L1 | ESTs L3i |
|---|---|---|---|---|---|---|---|---|---|
| SS00947.cl | C05D2.1 | daf-4 TGF-B receptor | 2e-22 | yes | see below | 0 | 3 | ||
| SS00947.cl | F29C4.1 | daf-1 kinase | 1e-07 | no | see above | 0 | 3 | ||
| SS01351.cl | F11A1.3 | daf-12, nuclear hormone receptor | 3e-58 | yes | F33D4.1 | nhr-8, nuclear hormone receptor | 8e-08 | 0 | 7 |
| SS03246.cl | R13H8.1 | daf-16 forkhead domain | 5e-46 | yes | R13H8.2 | 7e-29 | 1 | 0 | |
| SS02087.cl | R13H8.1 | daf-16 forkhead domain | 2e-13 | no | none | 1 | 0 | ||
| SS00592.cl | R13H8.1 | daf-16 forkhead domain | 1e-13 | no | F26D12.1 | fkh-7, forkhead domain | 1e-33 | 0 | 2 |
| SS03322.cl | R13H8.1 | daf-16 forkhead domain | 3e-07 | no | none | 1 | 0 | ||
| SS02393.cl | B0334.8 | daf-23 phosphoinositide 3-kinase | 3e-10 | no | F35H12.4 | phosphatidylinositol 4-kinase | 1e-57 | 0 | 1 |
| SS01344.cl | C15F1.b | sod-1 superoxide dismutase | 8e-64 | yes | see below | 2 | 5 | ||
| SS01344.cl | F55H2.1 | sod-4 superoxide dismutase | 1e-36 | no | see above | 2 | 5 | ||
| SS01344.cl | ZK430.3 | superoxide dismutase | 2e-57 | no | see above | 2 | 5 | ||
| SS01223.cl | C08A9.1 | sod-3 superoxide dismutase | 8e-72 | yes | F10D11.1 | sod-2 superoxide dismutase | 3e-74 | 4 | 1 |
| SS00590.cl | C11E4.1 | glutathione peroxidase | 2e-90 | yes | see below | 5e-82 | 0 | 2 | |
| SS00590.cl | C11E4.2 | glutathione peroxidase | 5e-82 | yes | see above | 2e-90 | 0 | 2 | |
| SS01468.cl | F26E4.12 | glutathione peroxidase | 2e-60 | yes | R05H10.5 | glutathione peroxidase | 2e-60 | 2 | 10 |
| SS01468.cl | R03G5.5 | glutathione peroxidase | 2e-54 | no | R05H10.5 | glutathione peroxidase | 2e-60 | 2 | 10 |
| SS00462.cl | T24H7.1 | prohibitin | 3e-41 | no | Y37E3.9 | prohibitin | 3e-80 | 2 | 0 |
| SS01126.cl | R11A8.4 | sir-2 silancing information regulator | 1e-17 | no | none | 1 | 3 | ||
| SS02217.cl | H42K12.1 | pdk-1 protein kinase | 7e-09 | no | none | 0 | 1 | ||
| SS02646.cl | T28B8.2 | ins-1 insulin like | 3e-12 | no | none | 0 | 1 | ||
| SS01374.cl | F38E11.2 | hsp-12, alpha-B-crystallin | 3e-9 | no | C14B9.1 | hsp-12, alpha-B-crystallin | 3e-13 | 0 | 8 |
| SS03005.cl | R02C2.3 | G-protein receptor | 2e-21 | no | T14D7.2 | 4e-100 | 1 | 0 | |
| SS00028.cl | T26C11.2 | novel | 1e-10 | no | Y22D7AR.1 | tyrosine phosphatase | 4e-16 | 0 | 136 |
| SS03404.cl | F36D3.9 | cysteine protease | 2e-08 | no | Y65B4A.2 | cysteine proteinase | 5e-45 | 1 | 0 |
| SS01412.cl | F22F1.1 | histone H1 | 3e-35 | yes | F59A7.4 | histone H1 | 3e-34 | 0 | 9 |
| SS00818.cl | F22F1.1 | histone H | 3e-40 | yes | M163.3 | his-24 histone | 2e-42 | 3 | 0 |
| SS01412.cl | C30G7.1 | histone H1 | 1e-18 | no | see above | 0 | 9 | ||
| SS00818.cl | C30G7.1 | histone H1 | 1e-24 | no | see above | 3 | 0 | ||
| SS00190.cl | C12D8.10 | akt-1 kinase | 5e-25 | no | B0545.1B | tpa-1 protein kinase | 2e-87 | 0 | 2 |
| SS03259.cl | C12D8.10 | akt-1 kinase | 3e-23 | no | T01H8.1B | spk-1 protein kinase C | 1e-44 | 1 | 0 |
| SS03125.cl | C12D8.10 | akt-1 kinase | 6e-27 | no | ZK303.2B | kin-1 protein kinase | 1e-34 | 0 | 1 |
| SS02139.cl | F56C9.1 | protein phosphatase 1 | 1e-73 | yes | F23F11.6 | serine/threonine phosphatase | 6e-73 | 1 | 0 |
| SS00017.cl | F56C9.1 | protein phosphatase 1 | 2e-51 | yes | F23F11.6 | serine/threonine phosphatase | 1e-55 | 1 | 3 |
| SS00691.cl | F56C9.1 | protein phosphatase 1 | 6e-37 | no | F38H4.3 | serine/threonine phosphatase | 1e-68 | 2 | 0 |
| SS00509.cl | F56C9.1 | protein phosphatase 1 | 4e-46 | no | C05A2.1 | serine/threonine phosphatase | 5e-54 | 0 | 2 |
| SS02292.cl | F56C9.1 | protein phosphatase 1 | 5e-45 | no | Y75B8A.30 | serine/threonine phosphatase | 3e-61 | 0 | 1 |
The following C. elegans genes with potential roles in dauer did not have S. stercoralis homologs among the clusters: Y55D5A.b, daf-2; ZC395.6, gro-1; ZC395.2, clk-1; F25E2.5, daf-3; R10H10.2, spe-26; Y54G11A.6, ctl-1 catalase; B0412.2, daf-7; C08H9.5, cold-1; Y54G11A.5, peroxisomal catalase.
Selected C. elegans genes include those involved in signaling pathways for dauer entry and exit, genes known to play a role in dauer, and genes of interest with high levels of dauer expression in comparison to other stages (Jones et al. 2001).
a
The highest matching additional C. elegans homolog of the S. stercoralis cluster