Table 2.
S. stercoralis homologs | C. elegans gene | Description | E-value | Possible ortholog? | Other homologsa gene | Description | E-value | S. stercoralis L1 | ESTs L3i |
---|---|---|---|---|---|---|---|---|---|
SS00947.cl | C05D2.1 | daf-4 TGF-B receptor | 2e-22 | yes | see below | 0 | 3 | ||
SS00947.cl | F29C4.1 | daf-1 kinase | 1e-07 | no | see above | 0 | 3 | ||
SS01351.cl | F11A1.3 | daf-12, nuclear hormone receptor | 3e-58 | yes | F33D4.1 | nhr-8, nuclear hormone receptor | 8e-08 | 0 | 7 |
SS03246.cl | R13H8.1 | daf-16 forkhead domain | 5e-46 | yes | R13H8.2 | 7e-29 | 1 | 0 | |
SS02087.cl | R13H8.1 | daf-16 forkhead domain | 2e-13 | no | none | 1 | 0 | ||
SS00592.cl | R13H8.1 | daf-16 forkhead domain | 1e-13 | no | F26D12.1 | fkh-7, forkhead domain | 1e-33 | 0 | 2 |
SS03322.cl | R13H8.1 | daf-16 forkhead domain | 3e-07 | no | none | 1 | 0 | ||
SS02393.cl | B0334.8 | daf-23 phosphoinositide 3-kinase | 3e-10 | no | F35H12.4 | phosphatidylinositol 4-kinase | 1e-57 | 0 | 1 |
SS01344.cl | C15F1.b | sod-1 superoxide dismutase | 8e-64 | yes | see below | 2 | 5 | ||
SS01344.cl | F55H2.1 | sod-4 superoxide dismutase | 1e-36 | no | see above | 2 | 5 | ||
SS01344.cl | ZK430.3 | superoxide dismutase | 2e-57 | no | see above | 2 | 5 | ||
SS01223.cl | C08A9.1 | sod-3 superoxide dismutase | 8e-72 | yes | F10D11.1 | sod-2 superoxide dismutase | 3e-74 | 4 | 1 |
SS00590.cl | C11E4.1 | glutathione peroxidase | 2e-90 | yes | see below | 5e-82 | 0 | 2 | |
SS00590.cl | C11E4.2 | glutathione peroxidase | 5e-82 | yes | see above | 2e-90 | 0 | 2 | |
SS01468.cl | F26E4.12 | glutathione peroxidase | 2e-60 | yes | R05H10.5 | glutathione peroxidase | 2e-60 | 2 | 10 |
SS01468.cl | R03G5.5 | glutathione peroxidase | 2e-54 | no | R05H10.5 | glutathione peroxidase | 2e-60 | 2 | 10 |
SS00462.cl | T24H7.1 | prohibitin | 3e-41 | no | Y37E3.9 | prohibitin | 3e-80 | 2 | 0 |
SS01126.cl | R11A8.4 | sir-2 silancing information regulator | 1e-17 | no | none | 1 | 3 | ||
SS02217.cl | H42K12.1 | pdk-1 protein kinase | 7e-09 | no | none | 0 | 1 | ||
SS02646.cl | T28B8.2 | ins-1 insulin like | 3e-12 | no | none | 0 | 1 | ||
SS01374.cl | F38E11.2 | hsp-12, alpha-B-crystallin | 3e-9 | no | C14B9.1 | hsp-12, alpha-B-crystallin | 3e-13 | 0 | 8 |
SS03005.cl | R02C2.3 | G-protein receptor | 2e-21 | no | T14D7.2 | 4e-100 | 1 | 0 | |
SS00028.cl | T26C11.2 | novel | 1e-10 | no | Y22D7AR.1 | tyrosine phosphatase | 4e-16 | 0 | 136 |
SS03404.cl | F36D3.9 | cysteine protease | 2e-08 | no | Y65B4A.2 | cysteine proteinase | 5e-45 | 1 | 0 |
SS01412.cl | F22F1.1 | histone H1 | 3e-35 | yes | F59A7.4 | histone H1 | 3e-34 | 0 | 9 |
SS00818.cl | F22F1.1 | histone H | 3e-40 | yes | M163.3 | his-24 histone | 2e-42 | 3 | 0 |
SS01412.cl | C30G7.1 | histone H1 | 1e-18 | no | see above | 0 | 9 | ||
SS00818.cl | C30G7.1 | histone H1 | 1e-24 | no | see above | 3 | 0 | ||
SS00190.cl | C12D8.10 | akt-1 kinase | 5e-25 | no | B0545.1B | tpa-1 protein kinase | 2e-87 | 0 | 2 |
SS03259.cl | C12D8.10 | akt-1 kinase | 3e-23 | no | T01H8.1B | spk-1 protein kinase C | 1e-44 | 1 | 0 |
SS03125.cl | C12D8.10 | akt-1 kinase | 6e-27 | no | ZK303.2B | kin-1 protein kinase | 1e-34 | 0 | 1 |
SS02139.cl | F56C9.1 | protein phosphatase 1 | 1e-73 | yes | F23F11.6 | serine/threonine phosphatase | 6e-73 | 1 | 0 |
SS00017.cl | F56C9.1 | protein phosphatase 1 | 2e-51 | yes | F23F11.6 | serine/threonine phosphatase | 1e-55 | 1 | 3 |
SS00691.cl | F56C9.1 | protein phosphatase 1 | 6e-37 | no | F38H4.3 | serine/threonine phosphatase | 1e-68 | 2 | 0 |
SS00509.cl | F56C9.1 | protein phosphatase 1 | 4e-46 | no | C05A2.1 | serine/threonine phosphatase | 5e-54 | 0 | 2 |
SS02292.cl | F56C9.1 | protein phosphatase 1 | 5e-45 | no | Y75B8A.30 | serine/threonine phosphatase | 3e-61 | 0 | 1 |
The following C. elegans genes with potential roles in dauer did not have S. stercoralis homologs among the clusters: Y55D5A.b, daf-2; ZC395.6, gro-1; ZC395.2, clk-1; F25E2.5, daf-3; R10H10.2, spe-26; Y54G11A.6, ctl-1 catalase; B0412.2, daf-7; C08H9.5, cold-1; Y54G11A.5, peroxisomal catalase.
Selected C. elegans genes include those involved in signaling pathways for dauer entry and exit, genes known to play a role in dauer, and genes of interest with high levels of dauer expression in comparison to other stages (Jones et al. 2001).
The highest matching additional C. elegans homolog of the S. stercoralis cluster