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. 2011 Dec 5;287(5):3197–3206. doi: 10.1074/jbc.M111.280271

FIGURE 2.

FIGURE 2.

Chimeras of CerS2 and CerS5. A, shown is a schematic representation of the three distinguishing domains of mammalian CerS5 and CerS2: Hox-like domain (stripes), TLC domain (gray), Lag1p motif (black). B, shown is a schematic representation of the 17 chimeras used in this study. The left column gives the name of the protein and the amino acid residues used; for instance, CerS2(1–143):CerS5(152–392) consists of the first 143 residues of CerS2 (in blue) and residues 152–392 of CerS5 (in pink); note the discrepancy in the numbering of CerS5 and CerS2, as CerS2 contains 12 residues less than CerS5. The abbreviated names used throughout the text are shown in the middle column. The right column shows a schematic representation of the chimeric proteins with CerS5 in pink and CerS2 in blue. The black vertical dotted lines indicate the beginning and end of the TLC domain, and the gray dotted vertical lines indicate the boundaries of the Lag1p motif.