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Summary of the importance of mitophagy in yeast. When yeast cells encounter starvation stress in respiratory growth, wild-type cells initiate mitophagy, degrade excess mitochondria, and suppress the production of ROS from mitochondria; as a result, the mitochondria escape oxidative damage. In mitophagy-deficient cells, the mitochondria suffer oxidative damage and produce more ROS that ultimately cause mtDNA mutation.
