TABLE 4.
Background: C. jejuni 81-176 | Polymyxin B MICa | pEtN modification (lipid A)b | pEtN modification (flagella) | Motilityc |
---|---|---|---|---|
μg/ml | % | |||
flgG | 17.3 ± 3.3 | + | + | 100 |
eptC | 0.8 ± 0.2 | − | − | 55 |
eptC, eptC+ | 17.6 ± 3.6 | + | + | 105 |
flgFG | 17.0 ± 3.0 | + | − | 0 |
flgFG, flgFGhis6(T75A)+ | 18.6 ± 4.6 | + | − | 55 |
flgFG, flgFGhis6(T75S)+ | 16.0 ± 0.0 | + | − | 55 |
flgFG, flgFGhis6(T75Y)+ | 18.6 ± 4.6 | + | − | 15 |
flgFG, flgFGhis6+ | 17.0 ± 3.0 | + | + | 100 |
a Minimum inhibitory concentrations were determined using polymyxin B Etest® strips (Biomérieux).
b Modification of lipid A by pEtN previously determined for strains wild type, eptC, and eptC, eptC+. Modification of lipid A by pEtN is assumed for other strains because of resistance to polymyxin B.
c Motility of indicated strains compared with that of wild type.