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. 2011 Dec 13;287(5):3366–3380. doi: 10.1074/jbc.M111.311241

FIGURE 3.

FIGURE 3.

RAD51C is dispensable for ICL unhooking and activation of FA pathway. A, V7B untreated and treated cells with MMC (100 ng/ml, 2 h) were monitored for ICL induction and processing. B, dose-dependent decrease in relative tail moment in V79B cells compared with untreated cells. C, time-dependent restoration of relative tail moment in V79B cells after treatment with 100 ng/ml MMC for 2 h. D, quantification of relative tail moment in V79B, CL-V4B vector, and RAD51C rescued cells. For each cell type 50 comets were scored using comet score software. Analysis of FANCD2 monoubiquitination after MMC- (E) and ionizing radiation (F)-induced DNA damage. Gy, gray.