FIGURE 4.
Equilibrium titration of CYP3A4 R212A (A), T224A (B), and R212A/T224A (C) with BEC. Absorbance changes in 4.3–4.7 μm CYP3A4 (a insets) were plotted against the BEC concentration (b insets). The derived Ks values are given in Table 2.
Equilibrium titration of CYP3A4 R212A (A), T224A (B), and R212A/T224A (C) with BEC. Absorbance changes in 4.3–4.7 μm CYP3A4 (a insets) were plotted against the BEC concentration (b insets). The derived Ks values are given in Table 2.