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. 2011 Dec 9;287(5):3559–3572. doi: 10.1074/jbc.M111.265744

FIGURE 4.

FIGURE 4.

ELF3 transactivates MMP13 and enhances the AP-1-driven MMP13 activation. Schematic representation (not scaled) of the MMP13-luciferase reporter constructs utilized in this study (A). T/C-28a2 cells were co-transfected with 325 ng of the −1602/+20 bp MMP13 promoter and 12.5, 25, or 50 ng of expression vector encoding human ELF3 (B); 25 ng of expression vector encoding human ELF3, alone or in co-transfection with 25 (+) or 50 (++) ng of ELF5 or EHF expression vector (C); or 25 ng of each expression vector encoding ELF3, c-Fos, and c-Jun alone or together (D). Luciferase activities are shown as fold-change; protein input was used to normalize luciferase activities in D. *, p < 0.05; ***, p < 0.001. Error bars, S.E.