Table 3.

Summary of Sequence Similarities Between Untranslated Regions and Coding Sequences of Human and Mouse Orthologous Overlapping Genes

	5′-UTR				CDS				3′-UTR
Overlap	no. of seq.	median	mean	std	no. of seq.	median	mean	std	no. of seq.	median	mean	std
Sequences that have overlaps in at least one of the species
Coding—coding	15	66.67	67.11	12.46	34	84.48	84.9	4.54	30	61.03	60.7	15.98
3UTR_Coding	102	60.96	61.75	15.09	185	85.36	84.66	4.95	165	63.23	63.35	13.52
5UTR_Coding	38	60.72	61.92	15.42	67	84.34	84	4.63	60	59.49	62.57	13.04
5UTR_5UTR	61	63.53	63.06	13.74	91	84.75	84.46	5.11	81	61.27	62.74	12.11
3UTR_3UTR	281	61.01	61.67	14.45	483	85.95	85.12	5.17	440	64.83	64.68	13.07
Sequences that have overlaps in both of the species
Coding—coding	0	0	0	N/A	0	0	0	N/A	0	0	0	N/A
3UTR_Coding	20	55.76	58.08	15.92	34	84.9	84.2	4.51	33	63.41	62.5	12.11
5UTR_Coding	1	72.7	72.7	N/A	2	88.97	88.97	2.89	2	69.48	69.48	5.79
5UTR_5UTR	3	72.52	69.53	5.33	4	86.71	85.3	6.04	4	69.48	69.94	10.97
3UTR_3UTR	74	60.7	61.26	15.41	124	85.34	85.02	4.8	120	69.06	68.27	11.47
Large scale human—mouse comparison (Makalowski and Boguski 1998)
	871	67	69.7	12.9	1,138	89	86.4	12.3	938	69.4	71	12.2

In bold are values that we expected to be significantly higher because of the overlap with another gene coding sequence and therefore be under higher selection against mutations.