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. 2011 Dec 20;11:38. doi: 10.1186/1471-2415-11-38

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Copyright ©2011 Clérin et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Spatio-temporal quantification of cones of rd1 flat retina during cones degeneration. (a) Virtual eye fundus representing the cone density measured by global automatic counting of cones labeled with PNA on flat-mounted wild-type and rd1 retinas from PN15 to PN90 (D: dorsal, V: ventral, T: temporal, N: nasal). The density of cones in each segment is encoded by a color scale and the absolute cone density value from dark blue, yellow to dark red are: 45, 90, 135, 180, 225, 270, 315, 360 and 405 cones/surface unit. (b) Average density of cones (cones/0.0376 mm²) in rd1 retina for the 9 rows centered on the optic nerve (peripheral to central) from PN15 to PN90. (c) PNA staining cones in rd1 flat-mounted retina at PN15 in central area of the retina (left) and peripheral area retina (right).