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. 2012 Feb 2;8(2):e1002458. doi: 10.1371/journal.pgen.1002458

Figure 3. Effects of Losartan and Apocynin on blood pressure and the angII/Ren pathway.

Figure 3

(A) Pre- and postnatal treatment with both losartan and apocynin effectively rescued the mean arterial blood pressure in conscious 16-week-old DD mice. (B) Treated DD mice had significantly reduced angII levels when compared to untreated DD littermates. (C) Relative Agt, Ace and Ren gene transcript levels in heart mRNA were also reduced in the losartan treated group when compared with untreated DD mice. Apocynin also showed moderate but significant effects. Data were normalized such that the mean of the wild-type group was 1.0 represented by the blue line. Only results from the post-natal onset groups for both treatments are represented, since data in the prenatal onset groups were very similar. *P<0.05 versus wild-type.; # P<0.05 versus untreated DD mice. The results represent the mean ± SD (n = 5–7 per group).