Figure 5. Sequence alignment of IRRDR (interferon/ribavirin resistance-determining region) and its upstream and downstream sequences of different HCV genotypes.

The residues in the region that corresponds to IRRDR of HCV-1b [11] are written in boldface letters. Dots indicate residues identical to the HCV-1b sequence. References of aligned sequences are: HCV-1b, El-Shamy et al. [11]; HCV-2a and -2b, Murakami et al. [8]; HCV-3a, X76918; HCV-4a, Y11604; HCV-5a, AF064490; HCV-6a, D84262; HCV-7a, EF108306.