. Author manuscript; available in PMC: 2013 Feb 1.

Published in final edited form as: J Am Chem Soc. 2012 Jan 18;134(4):2075–2084. doi: 10.1021/ja206995s

Table 1.

Selected Optimization Studies

graphic file with name nihms-339915-t0001.jpg

Entry^a	Solvent	Additive	ee^b (%)
1	PhCH₃	-	9
2	Et₂O	-	8
3	Dioxane	-	−11
4	DME	-	−16
5	THF	-	27
6	THF	9	37
7	THF	10	35
8	THF	11	27
9	THF	12	44
10	THF	13	38
11	THF	14	47
12	THF	15	51
13	THF	16	48
14	THF	17	65

All reactions run on a 0.47 mmol scale at 1M concentration in both donor 2 and acceptor 3.

Determined by chiral HPLC.