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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: J Am Chem Soc. 2012 Jan 18;134(4):2075–2084. doi: 10.1021/ja206995s

Table 5.

Influence of Ring Size of Additive on Enantioinduction.

graphic file with name nihms-339915-t0005.jpg

Entrya n Temp. (°C) Additive ee (%)b
1 1 rt 17 65
2 1 −20 17 82
3 1 −20 17 95c
4 2 −20 18 79
5 4 −20 19 80
a

All reactions run on a 0.47 mmol scale at 1M concentration in both donor and acceptor.

b

Determined by chiral HPLC.

c

Diazoester 2 added via slow addition using a syringe pump.