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Distinct migration patterns of self-tolerant and auto-reactive SP thymocytes within the medulla. Self-tolerant SP thymocytes migrate at high speeds making numerous contacts with the resident stromal cells. In contrast, auto-reactive SP thymocytes move slowly in confinement zones making slightly prolonged contacts with DCs. mTEC medullary thymic epithelial cells, DC dendritic cells, Mϕ macrophages
