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Egress from the thymus. Mature SP thymocytes express CD62L and the chemokine receptor S1P1 that are transcriptionally regulated by KLF2. They are attracted to S1P produced by pericytes and blood cells and transmigrate across the endothelial layer to enter the circulation. Cytoskeleton remodeling molecules such as Coronin 1A and mDia1 as well as small GTPase interacting molecules such as RapL and Mst1 are essential for the transmigration
