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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Exp Eye Res. 2011 Sep 24;95(1):8–15. doi: 10.1016/j.exer.2011.09.009

Figure 6. Effect of elevated cAMP on the (TNF-α)-induced response in bovine corneal endothelial monolayers.

Figure 6

Panel A: Co-treatment with 10 µM forskolin (F) and 50 µM rolipram (R) opposes the decline in TER induced by TNF-α. Panel B: Summary of experiments (n = 6) similar to that shown in Panel A. The % reduction in TER induced by the cytokine is greater than control after 8 hrs of exposure. Co-treatment opposes the (TNF-α)-induced reduction in TER after 12 hrs of exposure. * and ** denote p < 0.001 when comparing the (TNF-α)-treated group with the control group and (TNF-α+F+R)-treated group with the (TNF-α)-treated group, respectively. Panel C: Co-treatment with 20 µM NECA (N) and 50 µM R opposes the decline in TER induced by TNF-α. Panel D: Summary of experiments (n = 6) similar to that shown in Panel C. The % reduction in TER induced by the cytokine is greater than control after 8 hrs of exposure. Co-treatment opposes the (TNF-α)-induced reduction in TER after 12 hrs of exposure. * and ** denote p<0.001 when comparing the (TNF-α)-treated group with the control group and (TNF-α + N+R)-treated group with the (TNF-α)-treated group, respectively. Results summarized from our previous publication (Shivanna and Srinivas, 2010).