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Down regulation of CCN3/NOV in HSC by PDGF and TGF-β. a qRT-PCR, b Western blot and c ELISA of conditioned media showed that PDGF-B and -D as well as TGF-β significantly decrease expression of CCN3/NOV at both mRNA and protein levels in culture-activated HSC. d The inhibitory effect of PDGF was neutralized by a soluble PDGF-β receptor (soluble PDGFRβ, sR) that acts as a specific antagonist of PDGF-B and PDGF-D
