Fig. 1.

A) To determine the effect of tryptase and PGJ₂ on isolated adult cardiac fibroblast proliferation, BrdU incorporation was assayed immunocytochemically. Representative photographs of untreated fibroblasts (Panel A) and fibroblasts treated with tryptase (100 mU, Panel B), tryptase + FSRLLY(Panel C), and 15-d-PGJ₂ (10⁻⁶ M, Panel D), and counter stained with picrosirius red. B) Graphic illustration of the percent of BrdU-positive cells. Data represent five independent experiments.* denotes p ≤ 0.05 vs. control; # denotes p < 0.05 vs. tryptase