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Schematic diagram representing the hypothesis for mast cell mediated tryptase activation of PPAR induced remodeling. Release of mast cell derived tryptase binds the PAR-2 receptor leading to formation of COX2 and subsequent formation of 15-d-PGJ2 leading to binding of the nuclear receptor PPAR. [modified from Levi-Schaffer and Piliponsky (2003)]
