Table 1.
Baseline demographics and disease characteristics
| R-CHOP-14 (N = 409) | R-CHOP-21 (N = 702) | |||||
|---|---|---|---|---|---|---|
| FN | No FN | Overall | FN | No FN | Overalla | |
| N = 81 | N = 328 | N = 409 | N = 133 | N = 569 | N = 704 | |
| Age in years, mean ± SD | 61.1 ± 13.1 | 57.7 ± 15.0 | 58.4 ± 14.7 | 65.2 ± 11.8 | 62.0 ± 14.2 | 62.6 ± 13.8 |
| Age ≥65 years, n (%) | 39 (48) | 129 (39) | 168 (41) | 85 (64) | 275 (48) | 361 (51) |
| Female, n (%) | 42 (52) | 129 (39) | 171 (42) | 70 (53) | 265 (45) | 327 (46) |
| BMI in kg/m2, mean ± SD | 25.9 ± 4.4b | 25.4 ± 4.9c | 25.5 ± 4.8 | 25.5 ± 4.9 | 25.7 ± 4.4d | 25.7 ± 4.5 |
| ECOG performance status, n (%) | ||||||
| 0, 1 | 68 (84) | 304 (93) | 372 (91) | 100 (75) | 489 (86) | 591 (84) |
| 2, 3, 4 | 13 (16) | 18 (5) | 31 (8) | 24 (18) | 48 (8) | 72 (10) |
| Missing | 0 (0) | 6 (2) | 6 (1) | 9 (7) | 32 (6) | 41 (6) |
| Ann Arbor stage, n (%) | ||||||
| III | 22 (27) | 73 (22) | 95 (23) | 20 (15) | 117 (21) | 138 (20) |
| IV | 40 (49) | 108 (33) | 148 (36) | 57 (43) | 180 (32) | 237 (34) |
| IPI, n (%) | ||||||
| Low | 14 (17) | 110 (34) | 124 (30) | 26 (20) | 184 (32) | 211 (30) |
| Intermediate | 44 (54) | 166 (51) | 210 (51) | 60 (45) | 223 (39) | 284 (40) |
| High | 18 (22) | 18 (5) | 36 (9) | 26 (20) | 62 (11) | 88 (13) |
| Missing | 5 (6) | 34 (10) | 39 (10) | 21 (16) | 100 (18) | 121 (17) |
| Bone marrow involvement, n (%) | 14 (17) | 41 (13) | 55 (13) | 26 (20) | 83 (15) | 109 (15) |
| History of co-morbidities, n (%) | 48 (59) | 141 (43) | 189 (46) | 80 (60) | 292 (52) | 375 (53) |
| No prior treatmente, n (%) | 72 (89) | 299 (91) | 371 (91) | 122 (92) | 510 (90) | 634 (90) |
| Number of risk factors for FNf, n (%) | ||||||
| 0 | 5 (6) | 54 (16) | 59 (14) | 10 (8) | 93 (16) | 104 (15) |
| 1 | 16 (20) | 95 (29) | 111 (27) | 25 (19) | 137 (24) | 162 (23) |
| 2 | 23 (28) | 84 (26) | 107 (26) | 22 (17) | 148 (26) | 170 (24) |
| 3 | 14 (17) | 63 (19) | 77 (19) | 36 (27) | 102(18) | 139 (20) |
| ≥4 | 23 (28) | 32 (10) | 55 (13) | 40 (30) | 89 (16) | 129 (18) |
Known risk factors for FN are italicized
FN febrile neutropenia, BMI body mass index, ECOG Eastern Cooperative Oncology Group, IPI International Prognostic Index
aIncludes two patients for whom FN data were unavailable and who are excluded from other analyses presented
b n = 80
c n = 327
d n = 566
eNo chemotherapy, radiotherapy, or other prior treatment
fRisk factors are age ≥65 years; Ann Arbor stage III or IV; ECOG performance status ≥2; current or continuing cardiovascular, respiratory, renal, or hepatic/biliary co-morbidities; baseline serum albumin <35 g/L; baseline hemoglobin <12 g/dL; bone marrow involvement