. 2011 Jun 19;39(3):3123–3130. doi: 10.1007/s11033-011-1077-7

Table 4.

Results of gene–gene interactions analyzed by MDR method

Genes and rs numbers	Testing balanced accuracy^a	Cross validation consistency^b	P value^c
MTHFD1_rs2236225	0.4442	4/10	0.9980
MTR_rs1805087, TCN2_rs1801198	0.5181	5/10	0.7260
MTHFD1_rs2236225, TCN2_rs1801198, BHMT2_rs625879	0.4852	7/10	0.9480
MTHFR_rs1801133, MTR_rs1805087, MTRR_rs1801394, BHMT2_rs526264	0.5074	5/10	0.8130

^aTesting balanced accuracy of classification of cases and controls in the testing dataset calculated as (Sensitivity + Specificity)/2

^bCross validation consistency is the number of times the model was selected as the best model after tenfold cross validation runs

^cSignificance of accuracy, empirical P value based on 1,000 permutations