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. 2011 Dec 1;33(2):459–465. doi: 10.1093/carcin/bgr281

Fig. 3.

Fig. 3.

Quercetin-3-methyl ether is more potent than quercetin in suppressing growth and transformation of JB6 P+ cells. (A) Quercetin-3-methyl ether inhibits cell growth more strongly compared with quercetin. Cells were treated with 10 μM quercetin-3-methyl ether or quercetin in 5% FBS/EMEM and cell growth was measured by (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) assay at the indicated times. (B) Compared with quercetin, quercetin-3-methyl ether more strongly inhibits TPA-induced transformation of JB6 P+ cells. Cells were treated as described in Materials and methods and colonies were counted 14 days later under a microscope with the aid of Image-Pro Plus software (v.4). Data are shown as means ± SE. The asterisk (**) indicates a significant difference (P < 0.001) between groups treated with TPA and quercetin-3-methyl ether compared with the group treated with TPA and quercetin.