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. 2011 Dec 9;33(2):294–300. doi: 10.1093/carcin/bgr286

Fig. 4.

Fig. 4.

c-Myc overexpression partially rescues RhoA suppression by miR-34a. (A) A498 cells were transfected with pCMV6-ENTRY only (control) or pCMV6-ENTRY–c-Myc for 8 h followed by transfection with pre-miR NC or pre-miR-34a for 72 h. Protein level was analyzed by western blot. (B) c-Myc expression partially rescued inhibition of invasion induced by miR-34a. A498 cells were transfected with pCMV6-ENTRY only (control) or pCMV6-ENTRY–c-Myc for 8 h followed by transfection with pre-miR NC or pre–miR-34a for 48 h. Cells were harvested and subjected to transwell invasion assay. P < 0.05 compared with control. (B) Representative images of the invaded cells.