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Schematic model of miR-34a repression of c-Myc complexes. (A) The c-Myc–Skp2–Miz1 transcriptional complex activates RhoA. (B) miR-34a targets c-Myc and represses RhoA expression by suppressing the c-Myc–Skp2–Miz1 transcriptional complex. (C) The c-Myc–P-TEFb complex stimulates Pol II elongation. (D) miR-34a targets c-Myc and represses Pol II elongation by suppressing the c-Myc–P-TEFb elongation complex.
