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Kaplan-Meier survival curves, using a change of 20 points on the Appel ALS total score as the end point. Time to 20 points progression was estimated by assuming a linearity of the change in the Appel ALS total score. In two patients whose slope was not above zero (zero in one, and -0.33 point/month in the other, both treated with oral solubilized UDCA), the time to 20 point progression was estimated to be 60 months, i.e., 1 point/3 month.
